Borrelia burgdorferi is spirochete class bacterium. B. burgdorferi sensu stricto, B. burgdorferi sensu lato, B. burgdorferi afzelii and B. burgdorferi garinii spirochetes enter the human body through tick bites. Mixed with tick saliva, Borrelia travels through the circulation and enters different tissues. In some untreated cases, symptoms of pathogenic invasion have involved neurologic, cardiac, or joint disorders. Borrelia pathogenesis can break the blood-brain barrier, which allows invasion of the central nervous system, resulting in neuroborreliosis.
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