Arachidonic

Optimal result: 158 – 521 µmol/L

- A high Arachidonic acid level promotes gallstone formation by stimulating mucin production in the gallbladder mucosa.

- Arachidonic acid may trigger brain inflammation. High blood levels have been associated with a greater risk of suicide and depressive episodes.

- Animal protein from meat and fish has also been associated with a higher risk of inflammatory bowel disease such as ulcerative colitis and Crohn’s disease. Arachidonic acid has been identified as one possible reason why.

Potential treatment:

Reduce or eliminate consumption of animal products.

Reduced intake of animal meats and fats, or low dietary intake of omega-6 fatty acids in general, can result in lower levels of AA. Lack of vitamin and mineral cofactors for the desaturase and elongase enzymes upstream in omega-6 metabolism might contribute to lower levels.

Because of important immune and inflammatory signaling which requires AA, and its role in cell membrane phospholipid metabolism, lower levels of AA do have clinical significance. Psychiatric disorders such as schizophrenia, and neurologic disorders like tardive dyskinesia, show depletion of AA in RBC membranes. Improving AA levels decreased symptoms in some patients.

Monitoring levels and ensuring adequate dietary intake of AA is important in pregnant women, infants, children, and the elderly due to its importance for the development and optimization of the nervous system, skeletal muscle, and the immune system.

Arachidonic acid is an inflammatory omega-6 fatty acid. Our bodies produce this nutrient, and its excess may lead to inflammatory diseases and mood disorders.

Arachidonic acid is an inflammatory omega-6 fatty acid. Our bodies produce this nutrient, and its excess may lead to inflammatory diseases and mood disorders.

Because of the prevalence of corn and corn oil products in feed for cattle and hogs, diets high in these animal products are rich in arachidonic acid. 

Arachidonic acid is found in animal products, like poultry and eggs. The amount of arachidonic acid found in just one egg a day elevated arachidonic acid levels in the bloodstream, Japanese researchers learned.

Food sources of arachidonic acid, listed in descending order by percentages of their contribution to intake:

Rank Food item Contribution to intake (%) Cumulative contribution (%)
1 Chicken and chicken mixed dishes 26.9 26.9
2 Eggs and egg mixed dishes 17.8 44.7
3 Beef and beef mixed dishes 7.3 52.0
4 Sausage, franks, bacon, and ribs 6.7 58.7
5 Other fish and fish mixed dishes 5.8 64.5
6 Burgers 4.6 69.1

 

Arachidonic acid is a 20-carbon or fatty acid that serves as the principal pro-inflammatory fatty acid. Its synthesis is inhibited by non-steroidal anti-inflammatory drugs (NSAIDs).

Arachidonic Acid and Mental Health:

Arachidonic acid may trigger brain inflammation. High blood levels have been associated with a greater risk of suicide and depressive episodes. On the other hand, diets high in carbohydrate and low in fat and protein (with little or no arachidonic acid) may be associated with lower levels of anxiety and depression, according to epidemiological studies.

In one study, overweight or diabetic employees who went on a whole food, plant-based diet reported increased energy, better sleep patterns and improved mental health compared to a control group given no diet restrictions. Their work productivity also showed improvement.

A similar subsequent study of employees at 10 corporate sites showed notable improvements in depression, anxiety and emotional well-being among those following a meat-free, plant-based diet.

Arachidonic Acid and Inflammatory Bowel Disease:

Animal protein from meat and fish has also been associated with a higher risk of inflammatory bowel disease such as ulcerative colitis and Crohn’s disease. Arachidonic acid has been identified as one possible reason why. Even a semi-vegetarian diet has been shown to be highly beneficial in preventing relapses among patients suffering from Crohn’s disease.

References:

- https://epi.grants.cancer.gov/diet/foodsources/fatty_acids/table4.html

- https://nutritionfacts.org/topics/arachidonic-acid/

- https://www.ncbi.nlm.nih.gov/pubmed?term=20950616[uid]

- https://www.ncbi.nlm.nih.gov/pubmed/18774339

- https://www.ncbi.nlm.nih.gov/pubmed/12548439

Arachidonic
Healthmatters dashboard showing biomarker trend graph

Every lab result you’ve ever had, charted and explained.

Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.

Start with my report →
Beyond Arachidonic — 10,000+ markers explained
One Arachidonic result tells you where you are. Your history tells you where you’re heading. Upload your past lab reports and see this marker — and every marker on them —every marker charted against your own lab’s ranges.
Start with this report →
Healthmatters timeline preview showing biomarker trends over time
Clinical Sources & References

All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.

Article Review Log
Written by Healthmatters Editorial Team
Healthmatters Lifetime Plan

Pay $250. Track your health forever

One payment. No renewals. Yours for life.

10,000+ biomarkers explained · trends over time

See other plans →
Secure checkout via Stripe · GDPR & HIPAA
We accept results from any lab
LabCorp Quest Diagnostics Genova Diagnostics DUTCH Test Doctor's Data Vibrant America ZRT Laboratory Cyrex Labs + any other lab

What members are saying

★★★★★ 10,000+ happy members
★★★★★

"Watching my numbers move over the years — instead of forgetting last time's results — completely changed how I manage my health."

Daniel
Member since 2022
★★★★★

"Living across several countries made keeping my lab results organized a real challenge. Healthmatters brought my results from the USA, Spain, and Germany together — 20 years of history, with long-term trends instead of scattered reports."

Ben
Member since 2021 · tracks across countries
★★★★★

"Standard lab ranges are too wide for how I practice — 'normal' isn't optimal. I set my own bands, so a client sees yellow before a marker goes officially out of range. That's the conversation I want to be having."

Dr. Alexandra
Functional medicine · 6 yrs on Pro