Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein associated with the myelination of nerves in the central nervous system (CNS).
MOG is found in the myelin that insulates the nerves of the central nervous system (CNS), which consists of the brain, spinal cord and optic nerves. Damage to myelin causes disruption in the transmission of nerve signals in the body and a variety of symptoms.
Antibodies against MOG are found in various demyelinating diseases, including:
Multiple sclerosis
Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). In MS , the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between your brain and the rest of your body.
Neuromyelitis optica spectrum disorders (NMOSD)
Neuromyelitis optica spectrum disorder is a rare inflammatory disease that most often affects the optic nerves and spinal cord. Less often, it affects the brain. It often leads to sudden vision loss, paralysis or both. Symptoms after a first attack usually improve.
Idiopathic optic neuritis (ON)
Optic neuritis occurs when swelling (inflammation) damages the optic nerve — a bundle of nerve fibers that transmits visual information from your eye to your brain. Common symptoms of optic neuritis include pain with eye movement and temporary vision loss in one eye.
Acute disseminated encephalomyelitis (ADEM)
Acute disseminated encephalomyelitis (ADEM) is a neurological disorder characterized by brief but widespread attacks of inflammation (swelling) in the brain and spinal cord that damages myelin. Myelin is the whitish protective coating over nerves that helps with electrical nerve signaling. ADEM often appears following a viral or bacterial infection and sometimes (rarely) following a vaccination.
Multiphasic disseminated encephalomyelitis (MDEM)
Multiphasic disseminated encephalomyelitis (MDEM) is a rare peculiar diagnosis which is defined as acute demyelinating central nervous system disease with relapses occurring only within 4 weeks of initial manifestation.
Devic's disease
Devic's disease, also known as neuromyelitis optica, is a rare neurologic disorder that affects the eyes and spinal cord. It causes optic neuritis, a condition that typically leads to vision loss in one or both eyes, although many patients regain some sight.
Tumefactive demyelinating disease
Tumefactive demyelination or tumefactive multiple sclerosis are defined as demyelinating lesions (c. 2 cm or greater) or lesions between 0.5 and 2 cm with possible mass effect that can be mistaken for tumour-like space occupying lesions and have a characteristic radiographic appearance.
References:
Ambrosius W, Michalak S, Kozubski W, Kalinowska A. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Current Insights into the Disease Pathophysiology, Diagnosis and Management. Int J Mol Sci. 2020 Dec 24;22(1):100. doi: 10.3390/ijms22010100. PMID: 33374173; PMCID: PMC7795410.
Nakashima, I. (2015), Anti-myelin oligodendrocyte glycoprotein antibody in demyelinating diseases. Clin Exp Neuroimmunol, 6: 59-63. https://doi.org/10.1111/cen3.12262
Links:
https://www.ninds.nih.gov/health-information/disorders/acute-disseminated-encephalomyelitis
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/symptoms-causes/syc-20350269#:~:text=Multiple%20sclerosis%20(MS)%20is%20a,the%20rest%20of%20your%20body.
https://www.ohsu.edu/brain-institute/neuromyelitis-optica-spectrum-disorder-nmosd#:~:text=Neuromyelitis%20optica%20spectrum%20disorder%20is,a%20first%20attack%20usually%20improve.
https://www.mayoclinic.org/diseases-conditions/optic-neuritis/symptoms-causes/syc-20354953#:~:text=Optic%20neuritis%20occurs%20when%20swelling,vision%20loss%20in%20one%20eye.
https://www.ucsfbenioffchildrens.org/conditions/devics-disease#:~:text=Devic's%20disease%2C%20also%20known%20as,many%20patients%20regain%20some%20sight.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582300/#:~:text=Tumefactive%20demyelination%20or%20tumefactive%20multiple,have%20a%20characteristic%20radiographic%20appearance.
https://rarediseases.org/rare-diseases/mog-antibody-disease/
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If you have Anti-Myelin oligodendrocyte glycoprotein (IgG + IgA), it means that your immune system has produced both IgG and IgA antibodies that specifically target and bind to myelin oligodendrocyte glycoprotein.
The presence of anti-MOG antibodies, including IgG and IgA, can be indicative of an autoimmune disorder, such as multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). Both MS and NMOSD are chronic, progressive diseases of the central nervous system (CNS) that occur when the immune system attacks and damages the myelin sheath around nerve fibers.
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