5a-DHT is essential for the development of the male sex characteristics before birth, particularly the formation of the external genitalia. In the adult, 5a-DHT is needed to develop and maintain male gender characteristics, such as facial hair, deep voice, and muscle growth. In women, 5a-DHT may induce the onset of puberty and causes the body and pubic hair growth.
In males, about 70% of 5a-DHT is derived from conversion of testosterone by 5a-Reductase in the prostate, testes, hair follicles, and adrenal glands. In females most of the 5a-DHT is derived from androstenedione. 5a-DHT has approximately 3 times greater affinity for androgen receptors than testosterone and has 15-30 times greater affinity than adrenal androgens.
5a-Reductase is best known because it makes androgens like testosterone more potent. It is also responsible for metabolizing progesterone and cortisol. If up-regulated, it may cause high androgen symptoms in men (thinning hair, prostate) and women (as in PCOS, thinning hair, acne, facial hair growth). 5b-Metabolites are less androgenic (weaker).
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5a-DHT is a testosterone metabolite.
- If testosterone levels become too high, it usually results in excess of 5a-DHT, an androgen hormone and sex steroid. Both testosterone and 5a-DHT in excessive amounts can lead to a number of health issues.
- If your testosterone levels are in the normal range, but your 5a-DHT is increased it means that the alpha metabolic pathway is favored instead of the beta metabolic pathway.
List of possible symptoms for high 5a-DHT levels:
Female Androgenism:
Increased 5a-DHT levels are found in about 40% of patients with idiopathic hirsutism and 35% of patients with polycystic ovarian syndrome. Women with too much DHT may develop increased body, facial and pubic hair growth, amenorrhoea and increased acne. Abnormal changes to the genitalia may also occur in women with too much DHT.
Male Pattern Baldness (MPB):
5a-DHT is the primary contributing factor in male pattern baldness (MPB) or Androgenic alopecia. Men with MPB typically have higher levels of 5a-DHT, lower levels of total testosterone and higher levels of free testosterone.
Benign Prostatic Hyperplasia (BPH):
5a-DHT plays a role in the development and exacerbation of benign prostatic hyperplasia, as well as prostate cancer, by enlarging the prostate gland. Prostate growth and differentiation are highly dependent on sex steroid hormones, particularly 5a-DHT.
How to potentially address increased 5a-DHT levels:
If you are going down the alpha pathway towards 5a-DHT the symptoms are usually your typical PCOS-like symptoms like facial hair, acne, anger and irritation and hair loss on the head. Males might experience pattern baldness, prostate enlargement (BPH = Benign prostatic hyperplasia).
You might have completely normal levels of testosterone (please check your testosterone marker in this test to verity) and, yet, have a bad case of acne, are irritated or thinning scalp hair. If your 5alpha-DHT is increased this would be an indication that you are favoring the alpha pathway that’s quite aggressive on your skin, hair and other places. The reasons for your body choosing the alpha pathway can certainly be genetic, but it is often due to inflammation, blood sugar / insulin dysregulation, having extra adipose tissue, etc.. If you can address these underlying issues then your body will balance out the alpha and beta pathways and it will improve the symptoms.
In addition to addressing the underlying conditions (inflammation, glucose/insulin dysregulation, etc), there are things that can be done from a lifestyle perspective to mitigate the symptoms by blocking the alpha pathway, such as:
(before starting a supplement regime, please consult your doctor first)
- Zinc
- Saw palmetto
- Stinging and dwarf nettle
- Pygeum extract (bark)
- Reishi mushroom
Anthony
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As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
High levels of 5a-DHT can increase your risk for certain conditions, but having too little 5a-DHT can also cause problems in your sexual development as you go through puberty.
Low 5a-DHT may cause delays in the onset of puberty for all sexes. Otherwise, low 5a-DHT doesn’t appear to have much effect on women, but in men, low 5a-DHT may cause:
- late or incomplete development of sex organs, such as the penis or testes
- changes in body fat distribution, causing conditions such as gynecomastia
- increase in risk of developing aggressive prostate tumors
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Anthony
Unlimited Plan Member since 2021
I have been using Healthmatters.io since 2021. I travel all over the world and use different doctors and health facilities. This site has allowed me to consolidate all my various test results over 14 years in one place. And every doctor that I show this to has been impressed. Because with any health professional I talk to, I can pull up historical results in seconds. It is invaluable. Even going back to the same doctor, they usually do not have the historical results from their facility in a graph format. That has been very helpful.
Karin
Advanced Plan Member since 2020
What fantastic service and great, easy-to-follow layouts! I love your website; it makes it so helpful to see patterns in my health data. It's truly a pleasure to use. I only wish the NHS was as organized and quick as Healthmatters.io. You've set a new standard for health tracking!
Paul
Healthmatters Pro Member since 2024
As a PRO member and medical practitioner, Healthmatters.io has been an invaluable tool for tracking my clients' data. The layout is intuitive, making it easy to monitor trends and spot patterns over time. The ability to customize reports and charts helps me present information clearly to my clients, improving communication and outcomes. It's streamlined my workflow, saving me time and providing insights at a glance. Highly recommended for any practitioner looking for a comprehensive and user-friendly solution to track patient labs!
Healthmatters is a highly-personalized health dashboard.
Instead of searching for your lab results in different places or tracking them down from different providers, Healthmatters houses, organizes, and interprets them all in one central location.
With a Healthmatters account, you can dive into the details of each biomarker and gain insights into the meaning behind your medical test data, anytime, anywhere.
For our professional users, Healthmatters provides intuitive tools that not only streamline analysis but also save valuable time when delving into your client's lab report history.
Healthmatters.io personal account provides in-depth research on 4000+ biomarkers, including information and suggestions for test panels such as, but not limited to:
You can combine all test reports inside your Healthmatters account and keep them in one place. It gives you an excellent overview of all your health data. Once you retest, you can add new results and compare them.
If you are still determining whether Healthmatters support your lab results, the rule is that if you can test it, you can upload it to Healthmatters.
While we work with many popular labs, we welcome reports from lots of other places too.
It's as simple as this: if you can get a test done, you can upload it to Healthmatters and we can interpret results from any lab out there. If laboratories can analyze it, we can interpret it.
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Simply log in and navigate to your account settings to cancel your subscription. Scroll down to locate the 'Cancel' button at the bottom of the page. Ensure you cancel at least one day before the renewal date to prevent any charges. Once cancellation is requested, the subscription remains active until the conclusion of the current billing cycle.
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We’ve crafted multiple ways for you to navigate your data, whether you're glancing at a single report or delving into your historical test reports.
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Yes, you can download information from your account. We can compile your labs into a CSV file. To download all your labs, you can go to Account Settings, and at the bottom of the page, you will find a link to download your information.
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Yes, you can. When entering values for the biomarker, you will see an "Edit Range" button. Click this button, and you'll have the option to enter a custom range.
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16a-OH Estrone, 2-MeO E1/2-OH E1, 2-MeO Estradiol, 2-MeO Estrone, 2-OH (E1 + E2)/16-a- OH E1, 2-OH Estradiol, 2-OH Estrone, 20a- Dihydroprogesterone, 3a- Dihydroprogesterone, 3a-Dihydroprogesterone (Postmenopausal), 4-MeO E1/4-OH E1, 4-MeO E2/4-OH E2, 4-MeO Estradiol, 4-MeO Estrone, 4-OH Estradiol, 4-OH Estrone, 5a,3a-Androstanediol, 5a,3a-Androstanediol (Postmenopausal), 5a-DHT, 5a-DHT (Postmenopausal), Allopregnanediol, Allopregnanediol (Postmenopausal), Allopregnanolone, Allopregnanolone (Postmenopausal), Androstenedione, Androsterone, Androsterone (Postmenopausal), Bisphenol A, Bisphenol A (Postmenopausal), Corticosterone, Cortisol/Cortisone, Creatinine (1st morning), Creatinine (2nd morning), Creatinine (Evening), Creatinine (Night), Creatinine (pooled), Deoxycorticosterone, DHEA, E3/(E1+E2), Epi-Testosterone, Estradiol, Estriol, Estrone, Etiocholanolone, Free Cortisol (1st Morning), Free Cortisol (2nd Morning), Free Cortisol (Evening), Free Cortisol (Night), Free Cortisone (1st Morning), Free Cortisone (2nd Morning), Free Cortisone (Evening), Free Cortisone (Night), Melatonin (1st Morning), Melatonin (2nd Morning), Melatonin (Evening), Melatonin (Night), Pgdiol/E2, Pregnanediol, T/Epi-T, Testosterone, Tetrahydrocortisol, Tetrahydrocortisone, Total Cortisol, Total Cortisone
