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Home › Research › Organic Acids: 3-Hydroxyglutaric acid
Organic Acids

3-Hydroxyglutaric acid

Optimal result: 0 – 4.9 mmol/mol
Vibrant Wellness
By Healthmatters Editorial Team
Peer-reviewed sources

- Elevated 3-hydroxyglutaric acid may occur in combination with glutaric and glutaconic acids.

- Slight elevations may indicate mitochondrial dysfunction.

Possible symptoms:

Symptoms of glutaryl CoA dehydrogenase deficiency are varied. Some individuals appear normal, while others display encephalopathy, autism, cerebral palsy, and additional neurological abnormalities.

Possible treatment:

Treatment includes adherence to a diet low in lysine and supplementation with carnitine.

3-Hydroxyglutaric is a marker for glutaryl CoA dehydrogenase deficiency.

3-Hydroxyglutaric is a marker of glutaryl CoA dehydrogenase deficiency. This enzyme is involved in the breakdown of lysine, hydroxylysine, and tryptophan, and is associated with the genetic disease, glutaric aciduria type 1.

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