2-Methoxy-E1 is produced from 2-OH-E1 through the COMT enzyme. Anti-cancerogenic effects have been ascribed to 2-OH-E1 and particularly 2-Methoxy-E1.
The 2-Methoxy Estrogens are considered to be protective. Low levels are usually a reflection of overall low estrogens and may be improved with supplemental estrogen. Metabolized from 2-OH-E1. A comparison of 2-Methoxy-E1 with 2-OH-E1 allows insight into methylation pathways.
If the 2-Methoxy-E1 value is at least 25% (= 0.25) of 2-OH-E1 value, methylation is probably adequate. If <25% (less than 0.25) consider adding methyl donors.
Low methylation can be caused by low levels of nutrients needed for methylation and/or genetic abnormalities (COMT, MTHFR). The COMT enzyme responsible for methylation requires magnesium and methyl donors. Deficiencies in folate or vitamin B6 or B12 can cause low levels of methyl donors. MTHFR genetic defects can make it more difficult for patients to make sufficient methyl donors. Genetic defects in COMT can make methylation poor even in the presence of adequate methyl donors.
2-MeO E1/2-OH E1
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