While the traditional 2/16 ratio clinical utility may not be as robust as previously thought, a majority of findings indicate that metabolism of parent estrogens through 2-hydroxylation (independent of any relationship to 16α-OHE1) may be considered as a benign or even protective pathway.
Note: Moderation should be used, however, in up-regulating the "lesser estrogenic" 2- hydroxylation pathway, particularly in women with a positive family history of osteoporosis, since excessive 2-hydroxylation has been associated with decreased bone mineral density
2-Hydroxyestrone + 2-Hydroxyestradiol [2-OH(E1+E2)] / Menopause
Every lab result you’ve ever had, charted and explained.
Healthmatters is a tracker for your lab results. Upload a report from any lab, any country — every marker charted and explained.
Start with my report →
All our content is backed by peer-reviewed studies, academic research, and trusted medical sources. We’re committed to accuracy and transparency — see our editorial policy for details.